Treatment of juvenile rheumatoid arthritis

Adverse Effects of Synovectomy on Juvenile Rheumatoid Arthritis

One hundred fifty two patients with Juve­ nile rheumatoid arthritis were retrospectively studied in an effort to determine the efficacy of synovectomy in thi's disease.  Twenty-five of 117 closely observed patients underwent synovectomy following failure to be controlled by more conservative measures. Analysis of the end-results on the basis of age, sex, stage of disease, and individual joints...

Simultaneous Quadruple Joint Replacement (QJR) in Disabling Juvenile Rheumatoid Arthritis – a Case Report with Review of Literature

We wish to present a case of 47-year-old patient with Juvenile Rheumatoid Arthritis and ankylosis of both hips and bothknees treated by bilateral hip and knee arthroplasty in a single anaesthesia i.e. Quadruple joint replacement in singlesitting. He was back on his feet from his bed-ridden state within the fortnight following surgery. He has been followedup for four years and has been performin...

Anticardiolipin Antibodies in Juvenile Rheumatoid Arthritis and Systemic Lupus Erythematosus

Background: Antiphospholipid antibody syndrome (APS) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Anticardiolipin antibody (aCL) of IgG and/or IgM isotype in blood, measured by a standardized ELISA is the most acceptable laboratory criteria. APS IgG isotype, particularly IgG2 subclass is more strongly associated ...

Efficacy and Safety of Tocilizumab in the Treatment of Rheumatoid Arthritis and Juvenile Idiopathic Arthritis

Improving adherence to medical regimens for juvenile rheumatoid arthritis

Poor adherence to medical regimens can compromise the efficacy of treatments for children and adolescents with juvenile rheumatoid arthritis (JRA). The purpose of this review is to describe medical regimens for the treatment of JRA and the rates of adherence to these regimens. We also summarize and critically the few research studies aimed at improving adherence to regimens for JRA. Finally, we...

Tocilizumab (TCZ) may be an effective treatment for poly-juvenile idiopathic arthritis (pJIA) as for rheumatoid arthritis (RA)

Purpose TNF inhibitors are established treatment for poly-juvenile idiopathic arthritis (pJIA), but there are needs of alternative therapy for refractory patients. Tocilizumab (TCZ) has been widely used for rheumatoid arthritis (RA) in adults, and the effectiveness for systemic JIA has been well-documented. However, the experience on pJIA is limited. We compared the clinical courses of our pati...